Hydrochloric Acid → N-[2-(1-Benzofuran-3-yl)ethyl]formamide

HRID 652725Notes

Reaction equation

HRID 652725 reaction equation
[O:1]1[CH:5]=[C:4]([CH2:6][CH2:7][NH2:8])[C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2.[CH:13](OCC)=[O:14].Cl>>[CH:13]([NH:8][CH2:7][CH2:6][C:4]1[C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]=2[O:1][CH:5]=1)=[O:14]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 8025Ethyl formateHCID 124208122-Benzo[b]furan-3-ylethylamine

Product 1

HCID 13923851N-[2-(1-Benzofuran-3-yl)ethyl]formamide

Procedure

A solution of 2.35 g (0.015 mole) of 2-(3-benzo[b]furanyl)ethylamine and 5 mL of ethyl formate was heated at 60° C. for 3 hours, poured into 2N HCl and washed with methylene chloride which in turn was washed with 5% sodium hydroxide (w/v), dried (MgSO4), filtered and concentrated to give 2.70 g of product.

Workup

  1. washwashed with methylene chloride which in turn
  2. washwas washed with 5% sodium hydroxide (w/v)
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-e3353796cc544f0db271fd22430ad475
Source dataset
uspto-grants-1987_06
Patent number
US04673680

Reaction notes

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