Acetone → Benzamide

5.8 g of 2-methoxy-5-sulphamoyl benzoic acid, 50 ml of acetone, 10 ml of water and 3.6 ml of triethylamine (density 0.726) are placed in a 250 ml flask fitted with an agitator, a thermometer and a dropping funnel. The solution is cooled to about +10° C., then 3.6 g of isobutyl chloroformate is added drop by drop. The medium is reacted for 30 minutes at 0° C., after which 4.5 g of 1-cyclopropylmethyl-2-aminomethyl-pyrrolidine is poured in drop by drop. The medium is reacted for 1 hour at room temperature, 50 ml of water is added and the acetone is evaporated under vacuum. The reaction medium is further diluted with 50 ml of water and made alkaline with 10 ml of ammonia (density 0.91). The viscous product which is precipitated crystallises slowly. The solid is filtered off, washed with water and re-crystallised in 50 ml of ethanol. 3.8 g 841%) of benzamide is obtained, melting at 177° C.

1. customfitted with an agitator
2. temperatureThe solution is cooled to about +10° C.
3. customThe medium is reacted for 30 minutes at 0° C.
4. customThe medium is reacted for 1 hour at room temperature
5. customthe acetone is evaporated under vacuum
6. additionThe reaction medium is further diluted with 50 ml of water
7. customThe viscous product which is precipitated
8. customcrystallises slowly
9. filtrationThe solid is filtered off
10. washwashed with water
11. customre-crystallised in 50 ml of ethanol

ORD record

ord-5977863125654216a44a541b2732aade

Source dataset

uspto-grants-1987_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04673686