Hydrochloric Acid → HCID 14012558, compound

HRID 652861Notes

Reaction equation

HRID 652861 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[Cl:11])[C:5](Cl)=[O:6].[Al+3].[Cl-].[Cl-].[Cl-].[Cl:16][C:17]1[C:22]([Cl:23])=[CH:21][CH:20]=[CH:19][C:18]=1[O:24][CH3:25].Cl>ClCCCl>[Cl:23][C:22]1[C:17]([Cl:16])=[C:18]([O:24][CH3:25])[CH:19]=[CH:20][C:21]=1[C:5]([C:4]1[CH:8]=[CH:9][C:10]([Cl:11])=[C:2]([Cl:1])[CH:3]=1)=[O:6]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 161262,3-DichloroanisoleHCID 76403Benzoyl chloride, 3,4-dichloro-HCID 6451240Aluminum(III) Chloride

Product 1

HCID 14012558HCID 14012558, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent2×

Conditions

Temperature
60 °C

Procedure

To a solution of 57.6 g of 3,4-dichlorobenzoylchloride in 1,2-dichloroethane (150 ml) is added 36.7 g of AlCl3 in portions over a 30 minute period. To the resultant mixture is added dropwise 44.26 g of 2,3-dichloroanisole in 1,2-dichloroethane (150 ml). There is an evolution of gas and the reaction mixture is heated to 60° C. for one hour. The mixture is then poured over 150 ml of concentrated HCl and 150 ml of ice and then extracted with CHCl3 and then ethanol. The resultant organic layer is washed with 10% aqueous K2CO3, then water, dried over (Na2SO4) and evaporated to yield 2,3-dichloro-4-methoxy-3',4'-dichlorobenzophenone, mp 113°-140° C.

Workup

  1. extractionextracted with CHCl3
  2. washThe resultant organic layer is washed with 10% aqueous K2CO3
  3. dry with materialwater, dried over (Na2SO4)
  4. customevaporated

Sources & evidence

ORD record
ord-419a16ad11ed4c4286fea7ca1565d6df
Source dataset
uspto-grants-1987_06
Patent number
US04673746

Reaction notes

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