Hydrochloric Acid → HCID 14012559, compound

HRID 652862Notes

Reaction equation

HRID 652862 reaction equation
[Cl:1][C:2]1[C:17]([Cl:18])=[C:16]([O:19]C)[CH:15]=[CH:14][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[C:8]([Cl:13])[CH:7]=1)=[O:5].[Al+3].[Cl-].[Cl-].[Cl-].Cl.C(OC(=O)C)C>C1C=CC=CC=1>[Cl:1][C:2]1[C:17]([Cl:18])=[C:16]([OH:19])[CH:15]=[CH:14][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[C:8]([Cl:13])[CH:7]=1)=[O:5]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 6451240Aluminum(III) ChlorideHCID 14012558HCID 14012558, compound

Product 1

HCID 14012559HCID 14012559, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of 53 g of 2,3-dichloro-4-methoxy-3',4'-dichlorobenzophenone and 40 g AlCl3 in 400 ml of benzene is refluxed for five hours and then cooled to room temperature and maintained there for about 18 hours. The mixture is then poured over 200 ml of concentrated HCl and 200 ml of ice and then stirred at room temperature for one half hour. Ethylacetate is added to the mixture and the ethyl acetate/benzene layer is washed with water, dried over Na2SO4 and then evaporated to yield 2,3-dichloro-4-hydroxy-3',4'-dichlorobenzophenone, mp 179°-180° C.

Workup

  1. temperatureis refluxed for five hours
  2. temperaturemaintained there for about 18 hours
  3. washthe ethyl acetate/benzene layer is washed with water
  4. dry with materialdried over Na2SO4
  5. customevaporated

Sources & evidence

ORD record
ord-651cf4d3203041049d7173216930b136
Source dataset
uspto-grants-1987_06
Patent number
US04673746

Reaction notes

Loading…