2,3-Dichloroanisole → HCID 20150589, compound

HRID 652867Notes

Reaction equation

HRID 652867 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[O:9][CH3:10].[C:11]1([CH3:20])[C:12]([C:17](Cl)=[O:18])=[CH:13][CH:14]=[CH:15][CH:16]=1.[Al+3].[Cl-].[Cl-].[Cl-]>ClCCCl>[Cl:8][C:7]1[C:2]([Cl:1])=[C:3]([O:9][CH3:10])[CH:4]=[CH:5][C:6]=1[C:17]([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[CH3:20])=[O:18]

Participants

5

Reactant 3

HCID 161262,3-DichloroanisoleHCID 702762-Methylbenzoyl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 20150589HCID 20150589, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

The Friedel-Crafts procedure of Example 24a is repeated with 35.4 g of 2,3-dichloroanisole, 32.4 g of o-toluoyl chloride and 28 g of AlCl3 being combined in 125 ml of 1,2-dichloroethane to yield a product of 2,3-dichloro-4-methoxy-2'-methylbenzophenone.

Sources & evidence

ORD record
ord-ceb98956bcd649cc9cc69d6e2c373ed4
Source dataset
uspto-grants-1987_06
Patent number
US04673746

Reaction notes

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