alpha-(2,3-Dichloro-4-methoxyphenyl)-2-pyridinemethanol → (2,3-Dichloro-4-methoxyphenyl)(2-pyridyl)methanone

HRID 652874Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 652874
[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([O:9][CH3:10])[CH:5]=[CH:4][C:3]=1[CH:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)[OH:12]>C(O)(=O)C.O>[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([O:9][CH3:10])[CH:5]=[CH:4][C:3]=1[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)=[O:12]

Komponenten

4

Edukt 1

HCID 13015690alpha-(2,3-Dichloro-4-methoxyphenyl)-2-pyridinemethanol

Produkt 1

HCID 13015691(2,3-Dichloro-4-methoxyphenyl)(2-pyridyl)methanone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittel2×

Versuchsvorschrift

α-(2,3-dichloro-4-methoxyphenyl)-2-pyridinemethanol (31.86 g) is dissolved in 600 ml of acetic acid and 100 ml of H2O. Chromic anhydride (11.0 g) is added portionwise over five minutes. After three hours the reaction mixture is poured into H2O and extracted with ether. The combined organic phase is washed well with 10% NaHCO3, then brine and dried. Removal of the solvent under reduced pressure gives a crystalline product of (2,3-dichloro-4-methoxyphenyl)(2-pyridyl)methanone, mp 104°-107° C.

Aufarbeitung

  1. extractionextracted with ether
  2. washThe combined organic phase is washed well with 10% NaHCO3
  3. dry with materialbrine and dried
  4. customRemoval of the solvent under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1bb34bc2005e44fa9dab3b6ebdd2a1ac
Quelldatensatz
uspto-grants-1987_06
Patentnummer
US04673746

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