Sodium hydride → HCID 13015731, compound

HRID 652913Notes

Reaction equation

HRID 652913 reaction equation
[H-].[Na+].C(O/[N:7]=[C:8](\[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[F:25])/[C:9]1[C:14]([OH:15])=[CH:13][C:12]([O:16][CH3:17])=[CH:11][C:10]=1[Cl:18])(=O)C>CN(C=O)C>[Cl:18][C:10]1[C:9]2[C:8]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[F:25])=[N:7][O:15][C:14]=2[CH:13]=[C:12]([O:16][CH3:17])[CH:11]=1

Participants

4

Reactant 2

HCID 24758Sodium hydrideHCID 136477410HCID 136477410, compound

Product 1

HCID 13015731HCID 13015731, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

To a suspension of NaH (2.4 g) in 20 ml DMF, is added a solution of E-2-chloro-2'-fluoro-6-hydroxy-4-methoxybenzophenone O-acetyl oxime (15 g) in 50 ml DMF. After stirring at ambient temperature for two hours, the mixture is poured into one l ice-water, stirred for 30 minutes and a precipitate is collected. The precipitate is washed with water then dried to yield 4-chloro-3-(2-fluorophenyl)-6-methoxy-1,2-benzisoxazole, mp 113°-115° C.

Workup

  1. stirringstirred for 30 minutes
  2. customa precipitate is collected
  3. washThe precipitate is washed with water
  4. customthen dried

Sources & evidence

ORD record
ord-3099c55efa8a4fad93647144e3c6c900
Source dataset
uspto-grants-1987_06
Patent number
US04673746

Reaction notes

Loading…