反应详情

A solution of 6-chloro-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline (2 g), N,N-dimethylformamide dimethyl acetal (7.009 g), and triethylamine (0.87 g) in benzene (50 ml) was refluxed with stirring for 1 hour and then about three-fourths of the solvent was distilled slowly at atmospheric pressure over a period of approximately 1 hour. To the residue was added benzene (100 ml) and the solvent was distilled again. The resulting solid was collected by filtration, washed with diethyl ether, and dried to give 6-chloro-3-dimethylaminomethylene-4-oxo-1-propionyl-1,2,3,4-tetrahydroquinoline (2.02 g).

1. distillationabout three-fourths of the solvent was distilled slowly at atmospheric pressure over a period of approximately 1 hour
2. additionTo the residue was added benzene (100 ml)
3. distillationthe solvent was distilled again
4. filtrationThe resulting solid was collected by filtration
5. washwashed with diethyl ether
6. customdried