p-Toluenesulfonic acid monohydrate → p-Toluenesulfonic acid

HRID 653257Notes

Reaction equation

HRID 653257 reaction equation
FC1NC(=O)[C@@H]1NC(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.O.[C:28]1([CH3:38])[CH:33]=[CH:32][C:31]([S:34]([OH:37])(=[O:36])=[O:35])=[CH:30][CH:29]=1.N[C@H]1C(F)NC1=O>CC(C)=O>[CH3:38][C:28]1[CH:33]=[CH:32][C:31]([S:34]([OH:37])(=[O:36])=[O:35])=[CH:30][CH:29]=1

Participants

5

Reactant 3

HCID 521998p-Toluenesulfonic acid monohydrateHCID 53660755HCID 53660755, compoundHCID 54505091HCID 54505091, compound

Product 1

HCID 6101p-Toluenesulfonic acidYield 162.1%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of 3.3 g of (3S)-4-fluoro-3-tritylamino-2-oxoazetidine in 10 ml of acetone is added 1.82 g of p-toluenesulfonic acid monohydrate, and the mixture is treated in a same procedure to Reference Example 45B to give 2.67 g of p-toluenesulfonate of (3R)-3-amino-4-fluoro-2-oxoazetidine.

Workup

  1. additionthe mixture is treated in a same procedure to Reference Example 45B

Sources & evidence

ORD record
ord-157408c3b0fa4a6394aedf1e5ccdfb4e
Source dataset
uspto-grants-1987_06
Patent number
US04675397

Reaction notes

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