HCID 20027805, compound → HCID 20027819, compound

HRID 653475Notes

Reaction equation

HRID 653475 reaction equation
[CH:1]([N:4]1[C:9](=[O:10])[CH:8]2[CH2:11][C:6]([C:12]3[CH:17]=[CH:16][C:15]([N+:18]([O-])=O)=[CH:14][CH:13]=3)([CH2:7]2)[C:5]1=[O:21])([CH3:3])[CH3:2].C(OCC)(=O)C.CCCCCC>C(OCC)(=O)C.[Pd]>[NH2:18][C:15]1[CH:14]=[CH:13][C:12]([C:6]23[CH2:7][CH:8]([CH2:11]2)[C:9](=[O:10])[N:4]([CH:1]([CH3:2])[CH3:3])[C:5]3=[O:21])=[CH:17][CH:16]=1

Participants

5

Reactant 2

HCID 20027805HCID 20027805, compoundHCID 21226206Ethyl acetate hexane

Product 1

HCID 20027819HCID 20027819, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

In a manner analogous to that described in Example 1a, 2.3 g of 3-isopropyl-1-(4-nitrophenyl)-3-azabicyclo[-3.1.1]-heptane-2,4-dione are dissolved in 50 ml of ethyl acetate, hydrogenated in the presence of 0.25 g of 5% palladium-on-carbon and worked up. Melting point 191°-201° (from ethyl acetate/hexane).

Sources & evidence

ORD record
ord-b20c245036a445d3a06662ab4a9ebc16
Source dataset
uspto-grants-1987_06
Patent number
US04677129

Reaction notes

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