反应详情

N-Chlorosuccinimide (14,7 g) was added all at once to a solution of 4-(pyridin-3-yl)-thiazol-2-amine (17,7 g) in N,N-dimethylformamide (130 ml) at 0°-5° C. After five minutes, the product precipitated, and after ten minutes, precipitation was completed by addition of water and ammonium hydroxide solution. The product was filtered and dried in vacuo at 60° C. to give 5-chloro-4-(pyridin-3-yl)-thiazol-2-amine, (18,2 g) Mp 202° C.

1. customthe product precipitated
2. waitafter ten minutes
3. customprecipitation
4. additionwas completed by addition of water and ammonium hydroxide solution
5. filtrationThe product was filtered
6. customdried in vacuo at 60° C.