反应详情

To a solution of 7-Methyl-2-propylimidazo[4,5-b]pyridine (320 mg, 1.83 mmol) from Example 1 Step B in DMF (9 mL) at rt was added NaH (82 mg of an 80% dispersion in oil, 2.74 mmol). After 20 min., 2-cyano-3-(4-bromomethyl- phenyl)pyridine (600 mg, 2.19 mmol) was added and the mixture was stirred at rt for 3 h. Brine (100 mL) and aqueous NH4Cl (40 mL) were added and the product was extracted with EtOAc. Purification by flash chromatography (100% EtOAc) gave the above titled compound.

1. extractionthe product was extracted with EtOAc
2. customPurification by flash chromatography (100% EtOAc)