反应详情

40 g of the acid chloride ethyl ester of 3,3-dimethylglutaric acid, prepared in Example 28, are dissolved in 400 ml of tetrahydrofuran. 2 of 5% palladium-on-charcoal and 22.8 ml of 2,6-lutidine are added and the mixture is hydrogenated at normal pressure and room temperature. When the absorption of hydrogen has ceased, the catalyst is filtered off and the solvent is evaporated off under vacuum. The residue is taken up with water and extracted with ether. The ether phase is washed with a dilute solution of hydrochloric acid in the cold, washed with a solution of sodium bicarbonate in the cold, dried over magnesium sulfate and evaporated under vacuum to give, after distillation of the residue, 18 g of ethyl 4-formyl-3,3-dimethylbutanoate in the form of a liquid with a boiling point b.p.20 of 112°-118° C.

1. customis hydrogenated at normal pressure and room temperature
2. customWhen the absorption of hydrogen
3. filtrationthe catalyst is filtered off
4. customthe solvent is evaporated off under vacuum
5. extractionextracted with ether
6. washThe ether phase is washed with a dilute solution of hydrochloric acid in the cold
7. washwashed with a solution of sodium bicarbonate in the cold,
8. dry with materialdried over magnesium sulfate
9. customevaporated under vacuum
10. customto give
11. distillationafter distillation of the residue, 18 g of ethyl 4-formyl-3,3-dimethylbutanoate in the form of a liquid with a boiling point b.p.20 of 112°-118° C.