反应详情

To a solution of 2-butylbenzimidazole (0.52 g) in DMF (4 ml) was added, under cooling with ice, sodium hydride (60% oil, 0.13 g), and then the mixture was stirred for 20 minutes. To the resultant mixture was added methyl 2-(4-bromomethylphenyl)benzoate (1.0 g), which was stirred for 1.5 hour at room temperature. To the mixture was added water, followed by extraction with ethyl acetate. The solvent was evaporated to dryness to give an oily residue. The oil was purified by column chromatography on silica gel to obtain a colorless oil (1.2 g, quantitatively).

1. stirringwas stirred for 1.5 hour at room temperature
2. extractionfollowed by extraction with ethyl acetate
3. customThe solvent was evaporated to dryness
4. customto give an oily residue
5. customThe oil was purified by column chromatography on silica gel
6. customto obtain a colorless oil (1.2 g