反应详情

To a solution of N-(2-methoxy-6-nitrophenyl)valeramide (3.2 g) in DMF (15 ml) was added, under ice-cooling, sodium hydride (60% oil, 0.61 g). The mixture was stirred for 20 minutes and then there was added 4-(2-cyanophenyl)benzyl bromide (3.5 g), followed by stirring for one hour at room temperature. To the reaction mixture was added water, which was extracted with ethyl acetate. The organic layer was washed with water and dried. The solvent was distilled off, and the residue was purified by column chromatography on silica gel to give a yellow oil (5.8 g, quantitatively).

1. temperaturecooling
2. stirringby stirring for one hour at room temperature
3. extractionwas extracted with ethyl acetate
4. washThe organic layer was washed with water
5. customdried
6. distillationThe solvent was distilled off
7. customthe residue was purified by column chromatography on silica gel
8. customto give a yellow oil (5.8 g