反应详情

温度

-10 °C

Phosphorus pentachloride (500 mg) was dissolved in dry methylene chloride (5 ml). After cooling the resulting solution to -10° C., 2-(5-amino-1,2,4-thidiazol-3-yl)-(Z)-2-fluoromethoxyiminoacetic acid (325 mg) was added and the resulting mixture was stirred at the same temperature for 30 minutes. Isopropyl ether (20 ml) was added to the reaction mixture, and the resulting precipitate was collected by filtration to obtain the target product (130 mg).

1. filtrationthe resulting precipitate was collected by filtration