Diisopropyl Ether → HCID 14477683, compound

HRID 653854Notes

Reaction equation

HRID 653854 reaction equation
P(Cl)(Cl)(Cl)(Cl)[Cl:2].[NH2:7][C:8]1[S:12][N:11]=[C:10](/[C:13](=[N:17]/[O:18][CH2:19][F:20])/[C:14](O)=[O:15])[N:9]=1.C(OC(C)C)(C)C>C(Cl)Cl>[ClH:2].[NH2:7][C:8]1[S:12][N:11]=[C:10](/[C:13](=[N:17]/[O:18][CH2:19][F:20])/[C:14]([Cl:2])=[O:15])[N:9]=1

Participants

5

Reactant 3

HCID 7914Diisopropyl EtherHCID 24819Phosphorus pentachlorideHCID 11031360(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(fluoromethoxyimino)acetic acid

Product 1

HCID 14477683HCID 14477683, compoundYield 39.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
-10 °C

Procedure

Phosphorus pentachloride (500 mg) was dissolved in dry methylene chloride (5 ml). After cooling the resulting solution to -10° C., 2-(5-amino-1,2,4-thidiazol-3-yl)-(Z)-2-fluoromethoxyiminoacetic acid (325 mg) was added and the resulting mixture was stirred at the same temperature for 30 minutes. Isopropyl ether (20 ml) was added to the reaction mixture, and the resulting precipitate was collected by filtration to obtain the target product (130 mg).

Workup

  1. filtrationthe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-bd6c73543a4542af9d693f1322ae92ca
Source dataset
uspto-grants-1992_07
Patent number
US05128465

Reaction notes

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