Trifluoroacetic acid → HCID 131717449, compound

HRID 653856Notes

Reaction equation

HRID 653856 reaction equation
[C:1]1([CH2:7][C:8]([NH:10][C@@H:11]2[C:41](=[O:42])[N:13]3[C:14]([C:29]([O:31]CC4C=CC(OC)=CC=4)=[O:30])=[C:15](/[CH:18]=[CH:19]/[CH2:20][N+:21]([CH2:25][C:26](=[O:28])[NH2:27])([CH2:23][CH3:24])[CH3:22])[CH2:16][S:17][C@H:12]23)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[I-].[F:44][C:45]([F:50])([F:49])[C:46]([OH:48])=[O:47]>C1(OC)C=CC=CC=1>[F:44][C:45]([F:50])([F:49])[C:46]([O-:48])=[O:47].[C:1]1([CH2:7][C:8]([NH:10][C@@H:11]2[C:41](=[O:42])[N:13]3[C:14]([C:29]([OH:31])=[O:30])=[C:15](/[CH:18]=[CH:19]/[CH2:20][N+:21]([CH2:25][C:26](=[O:28])[NH2:27])([CH2:23][CH3:24])[CH3:22])[CH2:16][S:17][C@H:12]23)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 15435638HCID 15435638, compound

Product 1

HCID 131717449HCID 131717449, compound

Reagents, catalysts & solvents 1

HCID 7519AnisoleSolvent

Procedure

In a manner similar to Example 5, the compound (23 g) of Example 11 was suspended in anisole (130 ml), followed by an addition of trifluoroacetic acid (140 ml) to obtain the target product (15.9 g).

Sources & evidence

ORD record
ord-697aa86e8e234b7099fc4b17af6b71fa
Source dataset
uspto-grants-1992_07
Patent number
US05128465

Reaction notes

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