Trifluoroacetic acid → HCID 131717450, compound

HRID 653858Notes

Reaction equation

NC1SN=C(/[C:7](=N/OCF)/[C:8]([NH:10][C@@H:11]2[C:32](=[O:33])[N:13]3[C:14]([C:29]([O-:31])=[O:30])=[C:15](/[CH:18]=[CH:19]/[CH2:20][N+:21]([CH2:25][C:26](=[O:28])[NH2:27])([CH2:23]C)[CH3:22])[CH2:16][S:17][C@H:12]23)=[O:9])N=1.[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41].[C:45]1(OC)[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=1>>[F:38][C:39]([F:44])([F:43])[C:40]([O-:42])=[O:41].[C:45]1([CH2:7][C:8]([NH:10][C@@H:11]2[C:32](=[O:33])[N:13]3[C:14]([C:29]([OH:31])=[O:30])=[C:15](/[CH:18]=[CH:19]/[CH2:20][N+:21]([C@@H:25]([C:26](=[O:28])[NH2:27])[CH3:39])([CH3:22])[CH3:23])[CH2:16][S:17][C@H:12]23)=[O:9])[CH:46]=[CH:47][CH:48]=[CH:49][CH:50]=1

Participants

Reactant 3

HCID 6422Trifluoroacetic acid

HCID 7519Anisole

HCID 6536774Cefluprenam

Product 1

HCID 131717450HCID 131717450, compound

Procedure

In a similar manner as in Example 5, the compound (34.5 g) of Example 14 was suspended in anisole (210 ml), followed by an addition of trifluoroacetic acid (230 ml) to obtain the target compound (25.9 g).

Sources & evidence

ORD record: ord-b1b3598b01e04618bd12feda8544a772
Source dataset: uspto-grants-1992_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05128465

Reaction notes

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