1-Phenylpiperazine → HCID 9818685, compound

HRID 654071Notes

Reaction equation

HRID 654071 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(C(C)C)CC)(C)C.Br[CH2:23][CH2:24][N:25]1[C:33]2[C:28](=[N:29][CH:30]=[CH:31][CH:32]=2)[O:27][C:26]1=[O:34]>C(#N)C>[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:23][CH2:24][N:25]3[C:33]4[C:28](=[N:29][CH:30]=[CH:31][CH:32]=4)[O:27][C:26]3=[O:34])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 70961-PhenylpiperazineHCID 81531DiisopropylethylamineHCID 152074211-(2-Bromoethyl)[1,3]oxazolo[5,4-b]pyridin-2(1H)-one

Product 1

HCID 9818685HCID 9818685, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

In a round-bottomed flask under an argon atmosphere, surmounted by a condenser, 2.43 g (15 mmol) of 1-phenylpiperazine and then 2.61 cm3 (15 mmol) of diiso-propylethylamine are added to a solution of 2.43 g (10 mmol) of 1-(2-bromoethyl)-1H-oxazolo [5,4-b]pyrdin-2-one in acetonitrile.

Workup

  1. customIn a round-bottomed flask under an argon atmosphere, surmounted by a condenser

Sources & evidence

ORD record
ord-149be56809a342e9abf39751e1dacf7c
Source dataset
uspto-grants-1992_07
Patent number
US05130311

Reaction notes

Loading…