Chlorodiphenylmethane → 1,3-Dichloro-2-diphenylmethoxypropane

HRID 654080Notes

Reaction equation

HRID 654080 reaction equation
[C:1]1([CH:7](Cl)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:15][CH2:16][CH:17]([OH:20])[CH2:18][Cl:19]>C1(C)C=CC=CC=1>[Cl:15][CH2:16][CH:17]([O:20][CH:7]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH2:18][Cl:19]

Participants

4

Reactant 2

HCID 7035ChlorodiphenylmethaneHCID 72891,3-Dichloro-2-propanol

Product 1

HCID 123293381,3-Dichloro-2-diphenylmethoxypropaneYield 80%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A stirred solution of 508 g (2.5 mol) of diphenylmethylchloride and 387 g (3 mol) of 1,3-dichloro-2-propanol in 700 mL of dry toluene was heated at reflux temperature for 72 hr. The reaction mixture was concentrated in vacuo and the residual oil distilled to give 587 g (80%) of colorless oil; bp 137°-140° C./0.1 mm.

Workup

  1. temperatureat reflux temperature for 72 hr
  2. concentrationThe reaction mixture was concentrated in vacuo
  3. distillationthe residual oil distilled

Sources & evidence

ORD record
ord-a5ec3514365444e2a402bb23cb6688dd
Source dataset
uspto-grants-1992_07
Patent number
US05130309

Reaction notes

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