反应详情

温度

50 °C

160 g of 3-bromopropyl phenyl ether and 63 g of thiourea were dissolved in 300 ml of ethanol and the solution was refluxed with heating for 3 hours. A methanol solution containing 194 g of potassium hydroxide was added to the reaction solution and the mixture was stirred at 50° C. for 2 hours. The mixture was poured into diluted hydrochloric acid and extracted with ethyl acetate followed by distillation under reduced pressure to obtain 76.5 g of 3-phenoxypropanethiol. A boiling point was 135° to 138° C. at 17 mm Hg.

1. temperaturethe solution was refluxed
2. temperaturewith heating for 3 hours
3. additionwas added to the reaction solution
4. extractionextracted with ethyl acetate
5. distillationfollowed by distillation under reduced pressure