Hydrochloric Acid → HCID 22844972, compound

HRID 654235Notes

Reaction equation

HRID 654235 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][C@H:9]([C:13]([NH2:15])=O)[CH2:10]2)=[CH:5][CH:4]=1.[ClH:16]>C(O)(C)C>[ClH:16].[NH2:15][CH2:13][C@H:9]1[CH2:8][CH2:7][C:6]2[C:11](=[CH:12][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10632060HCID 10632060, compound

Product 1

HCID 22844972HCID 22844972, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

(ii') The salt is taken up in 0.1 N HCl, and the obtained solution is then extracted with ethyl acetate. The aqueous phase is made basic by the addition of a sodium carbonate solution and extracted with ethyl acetate. This last organic extract is then dried and evaporated to dryness to afford a residue which is dissolved in isopropanol. The compound of the title is then precipitated therefrom by the addition of hydrogen chloride saturated isopropanol and is recovered by filtration M.p. 228°-230° C.; [α]=-79.0° (c=1.4%, MeOH).

Workup

  1. extractionthe obtained solution is then extracted with ethyl acetate
  2. additionThe aqueous phase is made basic by the addition of a sodium carbonate solution
  3. extractionextracted with ethyl acetate
  4. extractionThis last organic extract
  5. customis then dried
  6. customevaporated to dryness
  7. customto afford a residue which
  8. customThe compound of the title is then precipitated
  9. additionby the addition of hydrogen chloride saturated isopropanol
  10. filtrationis recovered by filtration M.p. 228°-230° C.
  11. custom[α]=-79.0° (c=1.4%, MeOH)

Sources & evidence

ORD record
ord-1151cfb389ac49edbe2e3445dbeabd62
Source dataset
uspto-grants-1992_07
Patent number
US05130339

Reaction notes

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