Hydrochloric Acid → 1,3,5-Triazin-2-amine, 4-ethoxy-6-(trifluoromethyl)-

HRID 654265Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[C:6](C(Cl)(Cl)Cl)[N:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[N:3]=1.[CH2:16]([O-:18])[CH3:17].[Na+].O.Cl>C(O)C>[NH2:1][C:2]1[N:7]=[C:6]([O:18][CH2:16][CH3:17])[N:5]=[C:4]([C:12]([F:15])([F:14])[F:13])[N:3]=1

Participants

Conditions

Temperature: 20 °C

Procedure

20.0 g (71 mmol) of 2-amino-4-trichloromethyl-6-trifluoromethyl-1,3,5-triazine were added at 22° C. to a solution of 0.48 g (7.1 mmol) of sodium ethanolate in 100 ml of ethanol. The pale yellowish green solution was then refluxed for 30 minutes and, after cooling to 20° C., 20 ml of water were added and the mixture was neutralized with 2 normal hydrochloric acid. After this, most of the solvent was removed at 40° C. under reduced pressure, adding 100 ml of water a little at a time so that the solid did not agglomerate. The product was isolated in a similar manner to Example 2.

Workup

temperatureThe pale yellowish green solution was then refluxed for 30 minutes
customAfter this, most of the solvent was removed at 40° C. under reduced pressure
additionadding 100 ml of water a little at a time so that the solid
customThe product was isolated in a similar manner to Example 2

Sources & evidence

ORD record: ord-41bd7ecab63d4cb18639d21021e85079
Source dataset: uspto-grants-1992_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05130428

Reaction notes

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