Hydrochloric Acid → 4-Methoxy-6-(trifluoromethyl)-1,3,5-triazin-2-amine

HRID 654267Notes

Reaction equation

HRID 654267 reaction equation
C1CCN2C(=NCCC2)CC1.[NH2:12][C:13]1[N:18]=[C:17](C(Cl)(Cl)Cl)[N:16]=[C:15]([C:23]([F:26])([F:25])[F:24])[N:14]=1.Cl.[CH3:28][OH:29]>>[NH2:12][C:13]1[N:18]=[C:17]([O:29][CH3:28])[N:16]=[C:15]([C:23]([F:26])([F:25])[F:24])[N:14]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 110114464-(trichloromethyl)-6-(trifluoromethyl)-1,3,5-triazin-2-amine

Product 1

HCID 1999484-Methoxy-6-(trifluoromethyl)-1,3,5-triazin-2-amine

Conditions

Temperature
20 °C

Procedure

2.7 g (18 mmol) of 1,8-diazabicyclo[5.4.0]-7-undecene were added at 22° C. to a solution of 5 g (18 mmol) of 2-amino-4-trichloromethyl-6-trifluoromethyl-1,3,5-triazine in 25 ml of methanol. The mixture was refluxed for 1 hour and, after cooling to 20° C., made weakly acid (pH=6) with 2 normal aqueous hydrochloric acid. Then most of the solvent was removed under reduced pressure, after which the solid was isolated in a conventional manner.

Workup

  1. temperatureThe mixture was refluxed for 1 hour
  2. customThen most of the solvent was removed under reduced pressure
  3. customafter which the solid was isolated in a conventional manner

Sources & evidence

ORD record
ord-530f75c62e4d43bf9d9cb35dfa6af47d
Source dataset
uspto-grants-1992_07
Patent number
US05130428

Reaction notes

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