反应详情

A mixture of 2-n-butyl-4-chloro-1H-imidazole 5-carboxaldehyde (0.6 m=111.9 g), p-bromobenzylbromide (0.6 m=153.02 g), anhydrous potassium carbonate (0.75 m=103.5 g), and dry N,N-dimethylacetamide (900 mL) was stirred at room temperature for 4 hours. The mixture was diluted with 1.2 L of toluene and 1.8 L of water. After mixing for half an hour, the layers were separated. The organic layer was washed two more times with 900 mL portions of water, then dried over magnesium sulfate. The drying agent was removed by filtration and the filtrate was concentrated. The residual oil was pumped overnight to a weight of 191.71 g (89.9% yield).

1. additionAfter mixing for half an hour
2. customthe layers were separated
3. washThe organic layer was washed two more times with 900 mL portions of water
4. dry with materialdried over magnesium sulfate
5. customThe drying agent was removed by filtration
6. concentrationthe filtrate was concentrated
7. waitThe residual oil was pumped overnight to a weight of 191.71 g (89.9% yield)