Hydrogen Bromide → HCID 14441919, compound

HRID 654402Notes

Reaction equation

HRID 654402 reaction equation
[Cl:1][C:2]1[C:7]([O:8]C)=[CH:6][C:5]([N:10]=[C:11]2[N:15]3[CH2:16][CH2:17][CH2:18][CH2:19][CH:14]3[CH:13]([CH3:20])[O:12]2)=[C:4]([F:21])[CH:3]=1.Br.[OH-].[Na+]>>[Cl:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([N:10]=[C:11]2[N:15]3[CH2:16][CH2:17][CH2:18][CH2:19][CH:14]3[CH:13]([CH3:20])[O:12]2)=[C:4]([F:21])[CH:3]=1

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 14798Sodium HydroxideHCID 14441920HCID 14441920, compound

Product 1

HCID 14441919HCID 14441919, compound

Procedure

14.4 g 3-(4-Chloro-2-fluoro-5-methoxyphenylimino)-1-methylhexahydro-3H-oxazolo[3,4-a]pyridine was heated under reflux with 25 ml 48% hydrobromic acid for 5 hours. After cooling it was neutralised with 40% caustic soda and extracted with ethyl acetate. The organic phase was dried over magnesium sulphate, concentrated and the residue recrystallised from petroleum ether.

Workup

  1. temperatureAfter cooling it
  2. extractionextracted with ethyl acetate
  3. dry with materialThe organic phase was dried over magnesium sulphate
  4. concentrationconcentrated
  5. customthe residue recrystallised from petroleum ether

Sources & evidence

ORD record
ord-fdbe3db8c84a42fe8986ba3049eaa9bd
Source dataset
uspto-grants-1992_07
Patent number
US05131946

Reaction notes

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