反应详情

In 30 ml of dimethylformamide, 1.4 g of anhydrous potassium carbonate and 1.0 g of 1-chloro-2l-butene were added to 1.6 g of 3-aminobenzotrifluoride, followed by stirring for 2 hours from 70° C. to 90° C. After potassium carbonate was filtered off, 100 ml of saturated saline were added and the resulting mixture was extracted with benzene. The extract was dried over anhydrous sodium sulfate, concentrated and then subjected to chromatography on a silica gel column (hexane/ethyl acetate: 35/1, v/v), whereby the intended compound was obtained.

1. filtrationAfter potassium carbonate was filtered off
2. addition100 ml of saturated saline were added
3. extractionthe resulting mixture was extracted with benzene
4. dry with materialThe extract was dried over anhydrous sodium sulfate
5. concentrationconcentrated
6. custom35/1, v/v), whereby the intended compound was obtained