反应详情

A solution of 0.85 g of aniline in 20 ml of acetonitrile was dropwise added, while stirring, to a solution of 2.0 g of tetrafluoroisophthalonitrile and 2.0 g of triethylamine in 30 ml of acetonitrile. After dropwise adding, the mixture was stirred at room temperature for 1 hour and an aqueous sodium bicarbonate solution was then added. The mixture was extracted with chloroform and the chloroform extract was washed 5 times with an aqueous sodium chloride solution. After drying with magnesium sulfate, the chloroform was distilled off. The resultant crude crystal was purified by silica gel chromatography (solvent:hexane). Thus, 2.3 g (87% yield) of the desired compound No. 6 was obtained.

1. additionAfter dropwise adding
2. extractionThe mixture was extracted with chloroform
3. extractionthe chloroform extract
4. washwas washed 5 times with an aqueous sodium chloride solution
5. dry with materialAfter drying with magnesium sulfate
6. distillationthe chloroform was distilled off
7. customThe resultant crude crystal was purified by silica gel chromatography (solvent:hexane)