反应详情

To a suspension of 2.5 g (0.05 mol) of sodium hydride in a mixture of 40 ml of dry-dimethylacetamide and 40 ml of dry benzene, 0.05 mole of N-(2,6-dimethylphenyl)acetamide was added. After evolution of hydrogen ceased, the mixture was cooled in ice and water, and with stirring 0.075 mole of carbon disulfide was added slowly. The mixture was stirred at room temperature for 20 minutes. The reaction mixture was poured into water and extracted with toluene. The organic layer, dried over sodium sulfate, was evaporated, and distillation of the residue yielded 6.1 g (74%) of 2,6-dimethylphenylisothiocyanate.

1. additionin a mixture of 40 ml
2. additionwas added
3. temperaturethe mixture was cooled in ice
4. additionwas added slowly
5. extractionextracted with toluene
6. dry with materialThe organic layer, dried over sodium sulfate
7. customwas evaporated
8. distillationdistillation of the residue