Thionyl Chloride → HCID 10643405, compound

HRID 654785Notes

Reaction equation

HRID 654785 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:15][CH:14]=3)=[CH:11][C:10]([C:23]([OH:25])=O)=[N:9]2)=[CH:4][CH:3]=1.S(Cl)([Cl:28])=O>O1CCCC1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:15][CH:14]=3)=[CH:11][C:10]([C:23]([Cl:28])=[O:25])=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 10498716HCID 10498716, compound

Product 1

HCID 10643405HCID 10643405, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 1-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]pyrazole-3-carboxylic acid (6.4 g) and thionyl chloride (30 ml) in tetrahydrofuran (60 ml) was refluxed for 1 hour and concentrated under reduced pressure, giving 1-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]pyrazole-3-carbonyl chloride.

Workup

  1. temperaturewas refluxed for 1 hour
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-e14af48efe4f4b22b34db7842707a432
Source dataset
uspto-grants-1992_07
Patent number
US05134142

Reaction notes

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