Hydrochloric Acid → HCID 67851660, compound

HRID 654825Notes

Reaction equation

HRID 654825 reaction equation
[O-]CC.[Na+].[N:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]([O:13]CC)=O.[F:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][C:24]#[N:25])=[CH:19][CH:18]=1.Cl>C(O)C.O>[N:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]([OH:13])=[C:23]([C:24]#[N:25])[C:20]1[CH:21]=[CH:22][C:17]([F:16])=[CH:18][CH:19]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 17307Ethyl 2-pyridinecarboxylateHCID 68016Benzeneacetonitrile, 4-fluoro-HCID 2723922Sodium ethoxide

Product 1

HCID 67851660HCID 67851660, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of 40.8 g (0.60 mol) of sodium ethoxide in 200 ml absolute ethanol was added a mixture of 60.5 g (0.40 mol) of ethyl picolinate and 54.1 g (0.40 mol) of 4-fluorophenylacetonitrile. The solution was refluxed 10 minutes, then cooled to ambient temperature. The solids were dissolved by the addition of 330 ml of water. Then, 50 ml 12N hydrochloric acid was added dropwise. The solid was collected by filtration, washed with water, and dried overnight (30° C. in vacuo) to give 1-(2-pyridinyl)-2-cyano-2-(4-fluorophenyl)-ethen-1-ol. This compound was dissolved in 250 ml 48% hydrobormic acid and refluxed for 17 hours. Upon cooling, aqueous ammonium hydroxide was added until the reaction mixture was basic. The aqueous solution was extracted three times with chloroform. The combined organic extracts were washed with water, dried (MgSO4), and concentrated. The resulting solid was chromatographed on silica gel with ether-petroleum ether (1:3) as eluant, and recrystallized from 2-propanol-hexane to give the title Formula (X) compound, m.p. 56.58° C.

Workup

  1. temperatureThe solution was refluxed 10 minutes
  2. filtrationThe solid was collected by filtration
  3. washwashed with water
  4. customdried overnight (30° C. in vacuo)

Sources & evidence

ORD record
ord-a12a624a6b9b416f9efca7d8167fc76d
Source dataset
uspto-grants-1992_07
Patent number
US05134150

Reaction notes

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