HRID654960

反应详情

EQUATION

反应方程式

HRID 654960 的结构方程式

AUXILIARIES

试剂、催化剂与溶剂

2

PROCEDURE

实验过程

Potassium hydride (315 mg, 7.87 mmol) was added to a solution of 3-(2-naphthyl)propan-1-ol (1.33 g, 7.16 mmol) in tetrahydrofuran (10 ml) at room temperature under argon. After 1/2 hour, a solution of tributylstannylmethyliodide (3.09 g, 7.16 mmol) in tetrahydrofuran (2 ml) was added. After stirring at room temperature for 10 days, the mixture was diluted with hexane and washed thoroughly with water. Evaporation of the dried (magnesium sulphate) organic layer gave an oil, which was flash chromatographed on silica using 5% ethyl ether/petroleum ether. The title ether was obtained as a colorless oil.

WORKUP

后处理

  1. washwashed thoroughly with water
  2. customEvaporation of the
  3. dry with materialdried (magnesium sulphate) organic layer
  4. customgave an oil, which
  5. customchromatographed on silica using 5% ethyl ether/petroleum ether
  6. customThe title ether was obtained as a colorless oil