反应详情

A mixture comprising {1-[(1S,4R)-4-(2,6-dichloro purin-9-yl)-cyclopent-2-enyl]-1H-pyrazol-4-yl}-methanol (0.675 g, 1.92 mmol), diphenylethylamine (0.398 g, 2.02 mmol) and DIPEA (0.298 g, 2.31 mmol) in dry THF (20 mL) is stirred at 35 C for 3 days. The solvent is removed in vacuo and the resulting crude residue is partitioned between DCM and 0.1 M HCl. The organic portion is separated, washed with water, brine, dried (MgSO4) and concentrated in vacuo to afford the title product.

1. customThe solvent is removed in vacuo
2. customthe resulting crude residue is partitioned between DCM and 0.1 M HCl
3. customThe organic portion is separated
4. washwashed with water, brine
5. dry with materialdried (MgSO4)
6. concentrationconcentrated in vacuo