反应详情

温度

0 °C

(5,7-Difluoro-quinolin-6-yl)-acetic acid (1 g, 4.48 mmol) was added to an oven-dried round-bottom flask and suspended in dichloromethane (18 ml) The suspension was maintained under nitrogen atmosphere and cooled to 0° C. Next, the oxalyl chloride (470 uL, 5.38 mmol) was added slowly, followed by a catalytic amount of dimethylformamide. The solution was allowed to warm to room temperature over 2 hours. The solution was then concentrated in vacuo and dried via azeotropic distillation with toluene to afford the title compound. ES-MS m/z: 238 (M+H+) of methyl ester.

1. temperaturewas maintained under nitrogen atmosphere
2. temperatureto warm to room temperature over 2 hours
3. concentrationThe solution was then concentrated in vacuo
4. dry with materialdried via azeotropic distillation with toluene