Potassium Carbonate → HCID 59320232, compound

HRID 655280Notes

Reaction equation

HRID 655280 reaction equation
[C:1](=O)([O-])[O-:2].[K+].[K+].Cl[C:8]1[CH:9]=[CH:10][C:11]2[N:12]([C:14]([CH2:17][C:18]3[CH:19]=[C:20]4[C:25](=[CH:26][CH:27]=3)[N:24]=[CH:23][C:22]([C:28]3[CH:29]=[N:30][N:31]([CH3:33])[CH:32]=3)=[CH:21]4)=[N:15][N:16]=2)[N:13]=1>CO>[CH3:1][O:2][C:8]1[CH:9]=[CH:10][C:11]2[N:12]([C:14]([CH2:17][C:18]3[CH:19]=[C:20]4[C:25](=[CH:26][CH:27]=3)[N:24]=[CH:23][C:22]([C:28]3[CH:29]=[N:30][N:31]([CH3:33])[CH:32]=3)=[CH:21]4)=[N:15][N:16]=2)[N:13]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 59320311HCID 59320311, compound

Product 1

HCID 59320232HCID 59320232, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
130 °C

Procedure

To a 5 ml microwave vial 1 ml of methanol was added followed by 15 mg of potassium carbonate, and 25 mg (0.067 mmol) of 6-(6-chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-ylmethyl)-3-(1-methyl-1H-pyrazol-4-yl)quinoline. The reaction mixture was heated for 3800 seconds at 130° C. in a microwave. The reaction mixture was then filtered and purified by preparatory HPLC to return the title compound (11.6 mg, 47%). Analytical data is presented in Table 2.

Workup

  1. filtrationThe reaction mixture was then filtered
  2. custompurified by preparatory HPLC

Sources & evidence

ORD record
ord-34be63235c3e46a2b88a8d72b5f1bccb
Source dataset
uspto-grants-2011_12
Patent number
US08071581B2

Reaction notes

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