反应详情

温度

65 °C

10 g (100 mmol) of N-methylpiperazine are added to a solution of 2.4 g (10 mmol) of 3-chloropropyl (3-hydroxymethylphenyl)carbamate in 10 ml of acetonitrile. The solution is refluxed for 4 h. The mixture is then hydrolysed by addition of water and cooled to about 65° C., and ethyl acetate is added. The mixture is then cooled to room temperature, during which the product is obtained as a solid between the organic and aqueous phases. The product is filtered off and rinsed with water, acetonitrile and ethyl acetate. The product is subsequently dried at 50° C. for several hours; ESI: 308 (M+H).

1. temperatureThe solution is refluxed for 4 h
2. temperatureThe mixture is then cooled to room temperature, during which the product
3. customis obtained as a solid between the organic and aqueous phases
4. filtrationThe product is filtered off
5. washrinsed with water, acetonitrile and ethyl acetate
6. customThe product is subsequently dried at 50° C. for several hours