Hydrochloric Acid → HCID 67080751, compound

HRID 655559Notes

Reaction equation

HRID 655559 reaction equation
C(OC([N:11]1[CH2:17][CH2:16][C:15](=[O:18])[N:14]([C@H:19]([CH2:31][OH:32])[CH2:20][CH2:21][N:22]2[CH2:29][CH2:28][C:25]3([CH2:27][CH2:26]3)[C@H:24]([OH:30])[CH2:23]2)[CH2:13][CH2:12]1)=O)C1C=CC=CC=1.Cl>[Pd]>[OH:30][C@@H:24]1[CH2:23][N:22]([CH2:21][CH2:20][C@H:19]([N:14]2[C:15](=[O:18])[CH2:16][CH2:17][NH:11][CH2:12][CH2:13]2)[CH2:31][OH:32])[CH2:29][CH2:28][C:25]21[CH2:26][CH2:27]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67080621HCID 67080621, compound

Product 1

HCID 67080751HCID 67080751, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

In analogy to the procedure described in intermediate 5E, 4-[(S)-3-((S)-4-hydroxy-6-aza-spiro[2.5]oct-6-yl)-1-hydroxymethyl-propyl]-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester and 0.1 eq. of 1 M aq. hydrochloric acid solution and Pd/C was hydrogenated to give the title compound in quantitative yield as a white gum. MS: 312.2 (MH+).

Sources & evidence

ORD record
ord-9c66c2f23c2a4a24a5b533c45149ae42
Source dataset
uspto-grants-2011_12
Patent number
US08071586B2

Reaction notes

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