反应详情

To a solution of 2-(4-chlorophenoxy)ethanol (2.0 g, 11.6 mmol) in DCM (10 mL) was added Et3N (5 mL) and 4-methylbenzene-1-sulfonyl chloride (TsCl; 2.43 g, 12.8 mmol) sequentially. The reaction mixture was stirred at room temperature overnight and partitioned between water and ethyl acetate. The organic layer was washed with water, 5% sodium bicarbonate (NaHCO3), and brine and concentrated. The resulting residue was washed with hexane to afford the title compound quantitatively.

1. custompartitioned between water and ethyl acetate
2. washThe organic layer was washed with water, 5% sodium bicarbonate (NaHCO3), and brine
3. concentrationconcentrated
4. washThe resulting residue was washed with hexane