反应详情

温度

100 °C

5-bromo-3-(1,1-dioxidotetrahydro-2H-thiopyran-3-yl)-1H-indole-7-carboxylic acid (0.185 g, 0.497 mmol) was suspended in DMF (2 mL) with EDC (0.286 g, 1.49 mmol, 3 eq) and HOBt (0.076, 0.497 mmol) in a 10 mL microwave reaction vessel. 0.5M ammonia in 1,4-dioxane (1.9 mL, 0.9945 mmol, 2 eq) was added and heated on the microwave at 100° C. for 20 minutes. Reaction was diluted with water and extracted with ethyl acetate. The combined organics were washed with 1N NaOH, water, and brine then dried with magnesium sulfate, to give 0.161 g (87%) of the title compound.

1. customReaction
2. extractionextracted with ethyl acetate
3. washThe combined organics were washed with 1N NaOH, water, and brine
4. dry with materialthen dried with magnesium sulfate