Hydrochloric Acid → HCID 86588985, compound

HRID 656272Notes

Reaction equation

HRID 656272 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]([S:18][CH3:19])=[O:17])=[CH:11][CH:10]=1)(C)(C)C.[ClH:21]>C(OCC)(=O)C>[ClH:21].[CH3:19][S:18][C:16]([NH:15][C:12]1[CH:13]=[CH:14][C:9]([CH2:8][NH2:7])=[CH:10][CH:11]=1)=[O:17]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59684467HCID 59684467, compound

Product 1

HCID 86588985HCID 86588985, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
60 °C

Procedure

The compound 6-3 (22 mg) prepared in Step 2 was dissolved in ethyl acetate (1 ml) and to the solution was added 5 N aqueous hydrochloric acid (1 ml). The mixture was stirred at 60° C. for 1 hour and concentrated under reduced pressure to yield the compound 6-4 (15 mg, 100%).

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-abd6482b42a441d6a28e0b4ef4a5f906
Source dataset
uspto-grants-2011_12
Patent number
US08071650B2

Reaction notes

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