Phthalimide → HCID 86618991, compound

HRID 656281Notes

Reaction equation

HRID 656281 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]Cl)=[CH:4][N:3]=1.[C:10]1(=[O:20])[NH:14][C:13](=[O:15])[C:12]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:11]12>CN(C)C=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:19]2[CH:18]=[CH:17][CH:16]=[C:12]3[C:11]=2[C:10](=[O:20])[NH:14][C:13]3=[O:15])=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 6809PhthalimideHCID 1554792-Chloro-5-(chloromethyl)pyridine

Product 1

HCID 86618991HCID 86618991, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2-chloro-5-chloromethylpyridine (5 g) was dissolved in dimethylformamide (60 ml) and to the solution was added phthalimide (6.29 g), followed by stirring at room temperature for 17 hours. The solvent of the reaction solution was removed under reduced pressure and the residue was extracted with water and dichloromethane to yield a white solid (6.2 g, 74%).

Workup

  1. customThe solvent of the reaction solution was removed under reduced pressure
  2. extractionthe residue was extracted with water and dichloromethane

Sources & evidence

ORD record
ord-ef0d940bec9641acb9061442ea214676
Source dataset
uspto-grants-2011_12
Patent number
US08071650B2

Reaction notes

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