HCID 10225335, compound → HCID 178440922, compound

HRID 656306Notes

Reaction equation

HRID 656306 reaction equation
[C:1]([C:5]1[CH:29]=[CH:28][C:8]([CH2:9][NH:10][C:11]([NH:13][CH2:14][C:15]2[C:20]([F:21])=[CH:19][CH:18]=[C:17]([NH:22][S:23]([CH3:26])(=[O:25])=[O:24])[C:16]=2[F:27])=S)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[N:30]#[C:31][NH2:32].[Pb]>C(OCC)(=O)C>[C:31]([N:32]=[C:11]([NH:13][CH2:14][C:15]1[C:20]([F:21])=[CH:19][CH:18]=[C:17]([NH:22][S:23]([CH3:26])(=[O:25])=[O:24])[C:16]=1[F:27])[NH:10][CH2:9][C:8]1[CH:28]=[CH:29][C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:6][CH:7]=1)#[N:30]

Participants

4

Reactant 2

HCID 10225335HCID 10225335, compoundHCID 22262466CH2N2Pb

Product 1

HCID 178440922HCID 178440922, compoundYield 78.1%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1-(4-t-butylbenzyl)-3-(2,6-difluoro-3-methanesulfonylaminobenzyl)thiourea (44 mg) and lead cyanamide (30 mg) were added to ethyl acetate (10 ml) and the mixture was refluxed for 18 hours. The resulting mixture was purified by column-chromatogrphy (hexane/ethyl acetate=1/1) to yield the compound 31-7 (35 mg, 78%).

Workup

  1. temperaturethe mixture was refluxed for 18 hours
  2. customThe resulting mixture was purified by column-chromatogrphy (hexane/ethyl acetate=1/1)

Sources & evidence

ORD record
ord-c21b4c9ba8074ea691c90ca35df574fe
Source dataset
uspto-grants-2011_12
Patent number
US08071650B2

Reaction notes

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