反应详情

温度

80 °C

To a 1000 ml round-bottom flask fitted with a thermometer, a nitrogen-introducing tube, and a stirrer were added 132.2 g (1.0 mol) of 2,2-dimethyl-1,3-dioxolane-4-methanol, 231.4 g (1.2 mol) of a 28% methanol solution of sodium methoxide, and 500 ml of toluene. With introducing nitrogen thereinto, the toluene was refluxed under reduced pressure for 1 hour to remove the methanol by distillation. With maintaining the solution at 80° C., 126.6 g (1.0 mol) of benzyl chloride was added dropwise over a period of 2 hours using a dropping funnel, followed by further 2 hours of the reaction. The reaction solution was subjected to solvent removal and purification by distillation (b.p. 93-95° C./266 Pa) to obtain 4-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolane.

1. customTo a 1000 ml round-bottom flask fitted with a thermometer
2. additiona nitrogen-introducing tube, and a stirrer
3. customto remove the methanol
4. distillationby distillation
5. customfollowed by further 2 hours of the reaction
6. customThe reaction solution was subjected to solvent removal and purification by distillation (b.p. 93-95° C./266 Pa)