Hydrochloric Acid → HCID 131726886, compound

HRID 656435Notes

Reaction equation

HRID 656435 reaction equation
[ClH:1].[C:2]([C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[C@H:11]([NH:15][C:16]([NH:18][C:19]1[CH:27]=[CH:26][CH:25]=[C:24]3[C:20]=1[CH:21]=[N:22][NH:23]3)=[O:17])[CH2:10][CH2:9]2)([CH3:5])([CH3:4])[CH3:3]>C1COCC1>[ClH:1].[C:2]([C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[C@H:11]([NH:15][C:16]([NH:18][C:19]1[CH:27]=[CH:26][CH:25]=[C:24]3[C:20]=1[CH:21]=[N:22][NH:23]3)=[O:17])[CH2:10][CH2:9]2)([CH3:5])([CH3:3])[CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 11256560N'-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-N-1H-indazol-4-ylcarbamimidic acid

Product 1

HCID 131726886HCID 131726886, compoundYield 41.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Hydrochloric acid (37% aq, 17 mg) was added to a solution of compound of Example 13 (60 mg, 0.17 mmol) in THF 4 mL. After mixing for additional 15 h the precipitate was filtered off and dried to provide 27 mg (40%) of the salt. Differential scanning calorimetry and X-ray diffraction results are shown in FIGS. 3 and 4, respectively.

Workup

  1. additionAfter mixing for additional 15 h the precipitate
  2. filtrationwas filtered off
  3. customdried

Sources & evidence

ORD record
ord-b0332ade720f4a669685914cbdf64da1
Source dataset
uspto-grants-2011_12
Patent number
US08071762B2

Reaction notes

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