HCID 66915443, compound → HCID 178487333, compound

HRID 656485Notes

Reaction equation

HRID 656485 reaction equation
C([N:8]1[CH:12]=[C:11]([C:13]2([CH2:26][CH2:27][CH2:28][O:29]CC3C=CC=CC=3)[C:22]3[C:17](=[CH:18][C:19]([O:23][CH3:24])=[CH:20][CH:21]=3)[O:16][C:15](=[O:25])[CH2:14]2)[N:10]=[CH:9]1)C1C=CC=CC=1>CO.Cl.[Pd]>[OH:29][CH2:28][CH2:27][CH2:26][C:13]1([C:11]2[N:10]=[CH:9][NH:8][CH:12]=2)[C:22]2[C:17](=[CH:18][C:19]([O:23][CH3:24])=[CH:20][CH:21]=2)[O:16][C:15](=[O:25])[CH2:14]1

Participants

5

Reactant 1

HCID 66915443HCID 66915443, compound

Product 1

HCID 178487333HCID 178487333, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

A solution of 1 mmol of 4-(1-benzyl-1H-imidazol-4-yl)-4-(3-benzyloxypropyl)-7-methoxychroman-2-one in 15 ml of methanol and 2 ml of conc HCl is hydrogenated in the presence of 100 mg of 10% Pd/C at 15° C. for 10 hours. The reaction mixture is subjected to clarifying filtration and the filtrate is evaporated. The crude title compound is identified on the basis of the Rf value and reacted further without further purification.

Workup

  1. filtrationfiltration
  2. customthe filtrate is evaporated
  3. customreacted further without further purification

Sources & evidence

ORD record
ord-91a1030b3309497cb4da6f8a4f2b2a90
Source dataset
uspto-grants-2011_12
Patent number
US08071774B2

Reaction notes

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