Potassium Carbonate → HCID 66915478, compound

HRID 656490Notes

Reaction equation

HRID 656490 reaction equation
[N:1]1[C:10]2[CH2:9][CH2:8][CH2:7][C:6]3([CH2:12][O:11]3)[C:5]=2[CH:4]=[N:3][CH:2]=1.[Br:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][C:15]=1[OH:22].C(=O)([O-])[O-].[K+].[K+]>CC(O)C>[Br:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][C:15]=1[O:22][CH2:12][C:6]1([OH:11])[CH2:7][CH2:8][CH2:9][C:10]2[N:1]=[CH:2][N:3]=[CH:4][C:5]1=2

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 134938392-Bromo-5-methoxyphenolHCID 86637925HCID 86637925, compound

Product 1

HCID 66915478HCID 66915478, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A solution of 10 mmol of 7′,8′-dihydro-6′H-spiro[oxirane-2,5′-quinazoline] and 15 mmol of 2-bromo-5-methoxyphenol [63604-94-4] in 30 ml of 2-propanol is admixed with 20 mmol of finely powdered potassium carbonate. The mixture is heated at reflux for 12-18 hours, cooled and filtered over Hyflo. The filtrate is evaporated and from the residue the title compound is identified by means of flash chromatography (SiO2 60F) on the basis of the Rf value.

Workup

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 12-18 hours
  3. temperaturecooled
  4. filtrationfiltered over Hyflo
  5. customThe filtrate is evaporated and from the residue the title compound

Sources & evidence

ORD record
ord-81cc37a8597d4fcb852e026f41716ba1
Source dataset
uspto-grants-2011_12
Patent number
US08071774B2

Reaction notes

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