Dimethylformamide dimethyl acetal → HCID 66915648, compound

HRID 656493Notes

Reaction equation

HRID 656493 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]2[C:9]3([CH2:17][O:18][C:5]=2[CH:4]=1)[CH2:14][CH2:13][CH2:12][NH:11][CH:10]3[CH2:15][NH2:16].[CH3:19]OC(OC)N(C)C>ClCCl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]2[C:9]3([CH2:17][O:18][C:5]=2[CH:4]=1)[CH2:14][CH2:13][CH2:12][N:11]1[CH:19]=[N:16][CH2:15][CH:10]31

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 66915531HCID 66915531, compound

Product 1

HCID 66915648HCID 66915648, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 31 mmol of 1-(6-methoxyspiro[1-benzofuran-3,3′-piperidin]-2′-yl)methanamine and 31 mmol of N,N-dimethyl formamide dimethylacetal in 50 ml of dichloromethane is heated to reflux for 6 hours. The reaction mixture is cooled to room temperature and evaporated. The crude title compound is identified on the basis of the Rf value and reacted further without further purification.

Workup

  1. temperatureto reflux for 6 hours
  2. customevaporated
  3. customreacted further without further purification

Sources & evidence

ORD record
ord-4128eef8d5034ed6b61d76acd6f33747
Source dataset
uspto-grants-2011_12
Patent number
US08071774B2

Reaction notes

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