Trifluoroacetic acid → HCID 68995872, compound

HRID 656995Notes

Reaction equation

HRID 656995 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[F:12])[N:8]([CH2:13][CH2:14][N:15]1[CH2:20][CH2:19][CH:18]([N:21]([CH2:29][C:30]3[N:35]=[N:34][C:33]4[O:36][CH2:37][CH2:38][O:39][C:32]=4[CH:31]=3)C(=O)OC(C)(C)C)[CH2:17][CH2:16]1)[C:7](=[O:40])[CH:6]=[N:5]2.[F:41][C:42]([F:47])([F:46])[C:43]([OH:45])=[O:44]>C(Cl)Cl>[F:41][C:42]([F:47])([F:46])[C:43]([OH:45])=[O:44].[N:34]1[C:33]2[O:36][CH2:37][CH2:38][O:39][C:32]=2[CH:31]=[C:30]([CH2:29][NH:21][CH:18]2[CH2:17][CH2:16][N:15]([CH2:14][CH2:13][N:8]3[C:9]4[C:4](=[CH:3][C:2]([F:1])=[C:11]([F:12])[CH:10]=4)[N:5]=[CH:6][C:7]3=[O:40])[CH2:20][CH2:19]2)[N:35]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69186360HCID 69186360, compound

Product 1

HCID 68995872HCID 68995872, compoundYield 85.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 1,1-dimethylethyl {1-[2-(6,7-difluoro-2-oxo-1(2H)-quinoxalinyl)ethyl]-4-piperidinyl}(6,7-dihydro[1,4]dioxino[2,3-c]pyridazin-3-ylmethyl)carbamate (0.17 g, 0.305 mmol) in DCM (0.65 ml) was treated with trifluoroacetic acid (0.43 ml, 5.78 mmol) stirred at rt for 1 h and evaporated. The residue was triturated with ether and dried at 50° C. under vacuum to give the title compound (0.149 g).

Workup

  1. customevaporated
  2. customThe residue was triturated with ether
  3. customdried at 50° C. under vacuum

Sources & evidence

ORD record
ord-1fc27438639642d2b3963d3904604cc5
Source dataset
uspto-grants-2011_12
Patent number
US08071592B2

Reaction notes

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