反应详情

温度

80 °C

A mixture of 5-fluoro-3-nitro-1,2-benzenediol (6.55 g, 37.9 mmol), anhydrous potassium carbonate (21 g, 151.6 mmol) and 1,2-dibromoethane (8.2 mL) in DMF (70 ml) was heated at 80° C. under argon for 5 h. The reaction was cooled to rt, water (200 ml) added and the aqueous phase extracted with ethyl acetate (3×200 ml). The organics were washed with brine, dried, filtered and evaporated to afford the desired compound (6.96 g, 93%).

1. temperatureThe reaction was cooled to rt
2. extractionthe aqueous phase extracted with ethyl acetate (3×200 ml)
3. washThe organics were washed with brine
4. customdried
5. filtrationfiltered
6. customevaporated