Hydrochloric Acid → HCID 68992727, compound

HRID 657088Notes

Reaction equation

HRID 657088 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[N:11]=[N:10][C:9](=[O:12])[N:8]([CH2:13][CH2:14][N:15]3[CH2:20][CH2:19][CH:18]([NH:21]C(=O)OC(C)(C)C)[CH2:17][CH2:16]3)[C:7]=2[CH:29]=1.[ClH:30].C(OCC)(=O)C>C(Cl)(Cl)Cl.O1CCOCC1>[ClH:30].[ClH:30].[NH2:21][CH:18]1[CH2:19][CH2:20][N:15]([CH2:14][CH2:13][N:8]2[C:7]3[CH:29]=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][C:6]=3[N:11]=[N:10][C:9]2=[O:12])[CH2:16][CH2:17]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 86635351HCID 86635351, compound

Product 1

HCID 68992727HCID 68992727, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 1,1-dimethylethyl (1-{2-[6-(methyloxy)-3-oxo-1,2,4-benzotriazin-4(3H)-yl]ethyl}-4-piperidinyl)carbamate (48 mg, 0.11 g mmol) in chloroform (2 ml) was added 4M HCl in 1,4-dioxane (2 ml). The reaction was stirred at rt for 1 h before evaporation and trituration with ethyl acetate to provide the desired compound as a yellow oil which was used without further purification (42 mg, 94%).

Sources & evidence

ORD record
ord-722edbe4fb2d46dd95b3a3c6fb335857
Source dataset
uspto-grants-2011_12
Patent number
US08071592B2

Reaction notes

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